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研究领域：

主要从事稻种资源保护与创新利用方面研究，利用细胞学、遗传学和分子生物学等技术开展水稻生殖发育基因相关的调控机理，包括：（1）新型四倍体水稻的高育性调控机理研究，挖掘新型四倍体水稻中的育性调控基因，揭示其高育性的原因；（2）以不同倍性水稻为研究对象，围绕育性关键基因，比较其在不同倍性水稻中的调控机理差异。

教育经历：

        2001年 - 2005年 长江大学生命科学学院 理学学士     

        2007年 - 2010年  华南农业大学农学院 农学硕士

        2011年 - 2014年  华南农业大学农学院 农学博士

工作经历：

        2014年 - 2016年  江西省农业科学院水稻研究所 助力研究员

        2016年 - 2016年  美国South Dakota State University 访学研究

        2017年 -2023年   华南农业大学农学院助理研究员

        2024年-至今        华南农业大学农学院副教授

论文著作：（#为同等第一作者，*为通讯作者）

（1）第一作者或通讯作者论文

1. Hao Fan#, Kai Li, Mengzhu Hu, Zijun Huang, Haibin Guo, Xiang Li, Zhixiong Chen, Lan Wang, Shahid Muhammad Qasim, Xiangdong Liu, Jinwen Wu*. Cytological observation and transcriptome analysis reveal that NTFR1 is a new tetraploid rice fertility gene using the tetraploid fertility-directed lines, Plant Science, 2025, 355: 112437.

2. Zijuan Huang#, Peishan Huang, Shihui Chen, Mengzhu Hu, Hang Yu, Haibin Guo, Muhammad Qasim Shahid, Xiangdong Liu, Jinwen Wu*. Comparative cytological and gene expression analysis reveals that a common wild rice inbred line showed stronger drought tolerance compared with the cultivar rice. International Journal of Molecular Sciences, 2024, 25, 7134.

3. 林泓#, 黄子娟#, 邓瑞莲, 郭海滨，陆紫君，刘向东，吴锦文*. NaCl 胁迫下新型四倍体水稻种子萌发特性及基因差异表达分析. 华南农业大学学报, 2023, 44(5): 696-707.

4.  Tan Meimei#, Chen Ruoxin#, Chen Xingran, Shahid Muhammad Qasim, Liu Xiangdong, Wu Jinwen*. In vitro induction of interspecific hybrid and polyploidy derived from Oryza officinalis Wall, Plants (Basel), 2023, 20, 12(16): 3001.

5. Kamara Nabieu#, Jiao Yiamin#, Huang Weicong, Cao Lichong, Zhu Lianjun, Zhao Chongchong, Huang Xu, Fimanekeni Ndaitavela Shivute, Liu Xiangdong, Wu Jinwen*, Shahid Muhammad Qasim*. Comparative cytological and transcriptome analyses of ny2 mutant delayed degeneration of tapetal cells and promotes abnormal microspore development in neo-tetraploid rice, Frontiers in Plant Science, 2023, 14: 1229870.

6. Wu Jinwen#, Fan Hao, Hu Yifan, Guo Haibin, Lin Hong, Jiao Yinzhi, Lu Zijun, Du Susu, Liu Xiangdong, Shahid Muhammad Qasim*. Identification of stable pollen development related reference genes for accurate qRT-PCR analysis and morphological variations in autotetraploid and diploid rice, PLoS ONE, 2021, 16(6): e0253244.

7. Wu Jinwen#, Chen Yuanmou#, Lin Hong, Chen yang, Yu hang, Lu zijun, Li Xiang, Zhou hai, Chen Zhixiong, Liu Xiangdong*. Comparative cytological and transcriptome analysis revealed the normal pollen development process and up-regulation of fertility-related genes in newly developed tetraploid rice, International Journal of Molecular Sciences, 2020, 21(19): 7046.

8. Wu Jinwen#, Shahid Muhammad Qasim#, Chen Minyi#, Li Xiang, Li Jirui, Xu Xiaosong, Du Susu, Liu Xiangdong*. Cytological and transcriptome analysis reveal that interaction at Sb pollen sterility locus cause down-regulation of important meiosis-related genes associated with high pollen sterility in autotetraploid rice hybrids, Plant Physiology and Biochemistry, 2019, (141): 73-82.

9. Wu Jinwen#, Chen Lin#, Shahid Muhammad Qasim#, Chen Minyi, Dong Qinglei, Li Jirui, Xu Xiaosong, Liu Xiangdong*. Pervasive interactions of Sa and Sb loci cause high pollen sterility and abrupt changes in gene expression during meiosis that could be overcome by double neutral genes in autotetraploid rice, Rice, 2017, 10(49): 1-17.

10. Wu Jinwen#, Shahid Muhammad Qasim#, Chen Lin, Chen Zhixiong, Wang Lan, Liu Xiangdong*, Lu Yonggen*. Polyploidy enhances F1 pollen sterility loci interactions that increase meiosis abnormalities and pollen sterility in autotetraploid rice, Plant Physiology, 2015, 169(4): 2700-2717.

11. Wu Jinwen#, Shahid Muhammad Qasim#, Guo Haibin, Yin Wei, Chen Zhixiong, Wang Lan, Liu Xiangdong*, Lu Yonggen*. Comparative cytological and transcriptomic analysis of pollen development in autotetraploid and diploid rice, Plant Reproduction, 2014, 27(4): 181-196.

12. Wu Jinwen#, Hu Chaoyue#, Shahid Muhammad Qasim, Guo Haibin, Zeng Yuxiang, Liu Xiangdong*, Lu Yonggen*. Analysis on genetic diversification and heterosis in autotetraploid rice, Springer Plus, 2013, 2(439): 1-12.

参与作者：

    1. 刘向东，吴锦文，陆紫君，Shahid Muhammad Qasim. 同源四倍体水稻：低育性机理、改良与育种展望，遗传，2023， doi: 10.16288/j.yczz.23-074.

    2. 刘向东，吴锦文，Shahid Muhammad Qasim. 新型四倍体水稻创制及其杂种优势利用研究进展，生物技术通报，2021，37(8): 1-6.

   3. Chen Lin, Yuan Yun, Wu Jinwen, Chen Zhixiong, Wang Lan, Shahid Muhammad Qasim, Liu Xiangdong. Carbohydrate metabolism and fertility related genes high expression levels promote heterosis in autotetraploid rice harboring double neutral gene. Rice, 2019, 12: 34.

   4. Chen Lin, Shahid Muhammad Qasim, Wu Jinwen, Chen Zhixiong, Wang Lan, Liu Xiangdong. Cytological and transcriptome analyses reveal abrupt gene expression for meiosis and saccharide metabolisms that associated with pollen abortion in autotetraploid rice. Molecular Genetics and Genomics, 2018, 293(6): 1407-1420.

   5. Li Xiang, Shahid Muhammad Qasim, Wu Jinwen, Wang Lan, Liu Xiangdong, Lu Yonggen. Comparative small RNA analysis of pollen development in autotetraploid and diploid rice, International Journal of Molecular Sciences, 2016, 17(477): 1-23.

    6. Guo Haibin, Mendrikahy Jean Nestor, Xie Lei, Deng Junfeng, Lu Zijun, Wu Jinwen, Li Xiang, Shahid Muhammad Qasim, Liu Xiangdong. Transcriptome analysis of neo-tetraploid rice reveals specific differential gene expressions associated with fertility and heterosis, Scientific Reports, 2017, 7(40139): 1-11.

   7. Li Xiang, Shahid Muhammad Qasim, Xia Juan, Lu Zhijun, Fang Na, Wang Lan, Wu Jinwen, Chen Zhixiong, Liu Xiangdong. Analysis of small RNAs revealed differential expressions during pollen and embryo sac development in autotetraploid rice, BMC Genomics, 2017, 18(129):1-18

授权专利：

1. 袁赟，吴锦文，刘向东.培养皿拍照箱，实用新型专利，ZL 201721051622.2，授权公告日：2018.03.06

2. 刘向东，吴锦文，俞淑红，卡森，陈志雄，王兰.一种特大穗广亲和四倍体水稻的创制方法，ZL 201810291589.3，授权公告日：2021.10.29

主要合作品种：

1. 刘向东，卢永根，俞淑红，李亚娟，郭海滨，吴锦文. 水稻品种“华多1号”，植物新品种保护权，中华人民共和国农业部，编号：CNA008989E，2012年第5期.

2. .刘向东，卢永根，俞淑红，李亚娟，郭海滨，吴锦文. 水稻品种“华多2号”，植物新品种保护权，中华人民共和国农业部，编号：CNA008990E，2012年第5期.

承担科研项目情况： 

1. 国家自然科学基金-面上项目，转录因子MDDS特异调控水稻胚囊发育的分子机理及育种利用研究，2023-2026，在研，主持。

2. 广东省自然科学基金-面上项目，转录因子BPS1调控新型四倍体水稻花粉发育的分子机理，2023-2025，在研，主持。

3. 广东省自然科学基金-面上项目，泛素E3连接酶APS1调控新型四倍体水稻花粉发育过程的功能研究，2021-2023，结题，主持。

4. 广东省教育厅特色创新项目，泛素E3连接酶NTPS1调控水稻花粉发育的分子机理研究，2020-2022，结题，主持。

5. 广东省自然科学基金-面上项目，MADS-box相关基因在不同倍性水稻减数分裂期的功能比较研究，2018-2021，结题，主持。

6. 岭南现代农业科学与技术广东省自主科研项目双聘团队重大科技研究专项，同源（新型）四倍体水稻分子育种体系研究与材料创制，2021-2024，在研，主要参与。