贾津布

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贾津布   博士   首聘教授   课题组组长（PI）

研究领域：

水稻逆境适应和氮磷营养利用效率的分子调控机制

课题组拟利用自主开发的新生RNA全长测序技术和单细胞核全长转录组测序技术，结合多种遗传生化和分子生物学手段，从RNA转录、剪接、终止、加A和降解等多个层次研究RNA转录加工调控水稻逆境适应和氮磷营养利用效率的分子机制。

教育经历:

2008年-2012年 西北农林科技大学 学士学位

2012年-2017年 西北农林科技大学 博士学位

工作经历：

2017年-2019年 南方科技大学 博士后

2020年-2022年 南方科技大学 研究助理教授

2023年- 华南农业大学农学院 首聘教授

主要学术成果：

长期致力于植物RNA加工及其调控生长发育和环境响应机制的研究，以第一作者在Nature Plants（排名第一，两篇）、Plant Cell（排名第一）、Nature Protocols（排名第二）和Genome Biology（排名第三）上发表多篇研究论文。主要学术成果包括:

（1）通过开发和利用植物新生RNA全长测序技术FLEP-seq，深入研究了植物共转录和转录后RNA剪接加工机制，发现植物普遍存在转录后剪接现象，转录后剪接抑制介导的染色质滞留在植物基因表达调控中发挥重要作用;

（2）利用FLEP-seq深入研究了植物polyA长度调控机制，发现花粉和种子中polyA长度受到特异性调控；

（3）揭示大豆DCL2依赖的22-nt小RNA加工及其调控种皮颜色的机制;

（4）合作开发了植物单细胞核新生RNA全长测序技术，实现在单细胞水平同时检测基因表达和内含子剪接变化动态。

论文著作

1. Jinbu Jia^#; Wenqin Lu^#; Bo Liu; Yiming Yu; Xianhao Jin; Yi Shu; Yanping Long; Zhai Jixian*. An atlas of plant full-length RNA reveals tissue-specific and monocots–dicots conserved regulation of poly(A) tail length, Nature Plants, 2022, 8: 1118–1126.

2. Jinbu Jia^#; Yanping Long^#; Hong Zhang; Zhuowen Li; Zhijian Liu; Yan Zhao; Dongdong Lu; Xianhao Jin; Xian Deng; Rui Xia; Xiaofeng Cao; Jixian Zhai*; Post-transcriptional splicing of nascent RNA contributes to widespread intron retention in plants, Nature Plants, 2020, 6: 780-788.

3. Jinbu Jia^#; Ronghuan Ji^#; Zhuowen Li; Yiming Yu; Mayumi Nakano; Yanping Long; Li Feng; Chao Qin; Dongdong Lu; Junpeng Zhan; Rui Xia; Blake C. Meyers; Bin Liu*; Jixian Zhai*; Soybean DICER-LIKE2 Regulates Seed Coat Color via Production of Primary 22-Nucleotide Small Interfering RNAs from Long Inverted Repeats, The Plant Cell, 2020, 32: 3662-3673.

4. Yanping Long^#; Jinbu Jia^#; Weipeng Mo; Xianhao Jin; Jixian Zhai; FLEP-seq: simultaneous detection of RNA polymerase II position, splicing status, polyadenylation site and poly(A) tail length at genome-wide scale by single-molecule nascent RNA sequencing, Nature Protocol, 2021, 16(9):4355-4381.

5. Yanping Long^#; Zhijian Liu^#; Jinbu Jia^#; Weipeng Mo; Liang Fang; Dongdong Lu; Bo Liu; Hong Zhang; Wei Chen; Jixian Zhai*; FlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants, Genome Biology, 2021, 22(66).

6. Jinbu Jia^#; Wenqin Lu; Chengcheng Zhong; Ran Zhou; Junjie Xu; Wei Liu; Xiuhong Gou; Qinhu Wang; Junliang Yin; Cheng Xu; Weixing Shan*; The 25–26 nt Small RNAs in Phytophthora parasitica Are Associated with Efficient Silencing of Homologous Endogenous Genes, Frontiers in Microbiology, 2017, 8(773).

7. Hong Zhang^#; Jinbu Jia; Jixian Zhai*; Plant Intron-Splicing Efficiency Database (PISE): exploring splicing of ~1;650;000 introns in Arabidopsis; maize; rice; and soybean from ~57;000 public RNA-seq libraries, Science China Life Sciences, 2022

8. Zhuowen Li^#; Yanping Long^#; Yiming Yu; Fei Zhang; Hong Zhang; Zhijian Liu; Jinbu Jia; Weipeng Mo; Simon Zhongyuan Tian; Meizhen Zheng; Jixian Zhai*; Pore-C Simultaneously Captures Genome-wide Multi-way Chromatin Interaction and Associated DNA Methylation Status in Arabidopsis, Plant Biotechnology Journal, 2022, 20(6):1009-1011

9. Weipeng Mo^#; Bo Liu^#; Hong Zhang; Xianhao Jin; Dongdong Lu; Yiming Yu; Yuelin Liu; Jinbu Jia; Yanping Long; Xian Deng; Xiaofeng Cao; Hongwei Guo; Jixian Zhai*; Landscape of transcription termination in Arabidopsis revealed by single-molecule nascent RNA sequencing, Genome Biology, 2021, 22(1):322

10. Daoheng Hu^#; Yiming Yu^#; Chun Wang^#; Yanping Long; Yue Liu; Li Feng; Dongdong Lu; Bo Liu; Jinbu Jia; Rui Xia; Jiamu Du; Xuehua Zhong; Lei Gong; Kejian Wang*; Jixian Zhai*; Multiplex CRISPR-Cas9 editing of DNA methyltransferases in rice uncovers a class of non-CG methylation specific for GC-rich regions, Plant Cell, 2021, 33(9):2950-2964

11. Hong Zhang^#; Fei Zhang^#; Yiming Yu^#; Li Feng; Jinbu Jia; Bo Liu; Bosheng Li; Hongwei Guo; Jixian Zhai*; A comprehensive online database for exploring ∼20;000 public Arabidopsis RNA-Seq libraries, Molecular Plant, 2020, 13(9):1231-1233.

12. Guiyan Huang; Zhirou Liu; Biao Gu; Hong Zhao; Jinbu Jia; Guangjin Fan; Yuling Meng; Yu Du; Weixing Shan*; An RXLR effector secreted by Phytophthora parasitica is a virulence factor and triggers cell death in various plants, Molecular Plant Pathology, 2019, 20(3):356-371

13. Wenqin Lu^#; Fengyan Deng^#; Jinbu Jia; Xiaokang Chen; Jinfang Li; Qujiang Wen; Tingting Li; Yuling Meng; Weixing Shan; The Arabidopsis thaliana gene AtERF019 negatively regulates plant resistance to Phytophthora parasitica by suppressing PAMP-triggered immunity, Molecular Plant Pathology, 2020, 21:1179-1193