Caroline S. Harw

时间:2016-12-09浏览:20设置


Caroline S. Harwood

教授
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个人简介


 
    Caroline S. Harwood,在耶鲁大学完成博士后研究工作,2005年入职华盛顿大学前曾在康奈尔大学和爱荷华大学进行学术研究工作,为美国国家科学院、美国科学进步协会和美国科学院微生物学院士,2010年获得了应用与环境微生物学宝洁奖。本人实验室的一个重要研究领域为致病菌铜绿假单胞菌Pseudomonas aeruginosa的传感信号转导和生物膜形成,第二个重点领域涉及光合细菌沼泽红假单胞菌Rhodopseudomonas palustris(Rpal)的代谢多功能。本人近期与E. Peter Greenberg合作开发的研究项目还包括细菌细胞与细胞间通讯的新的群体感应信号的研究。同时,本人正在探索细菌和植物胡杨(Populus)之间的信号传导。在重要学术期刊发表论文100余篇,其中Nature论文3篇、Science论文1篇、PNAS论文6篇。现为广东省群体微生物基础理论与前沿技术创新团队核心成员,华南农业大学教授。

代表性论著(论文)
1.Hirakawa H, Schaefer AL, Greenberg EP, Harwood CS. 2012. Anaerobic p-coumarate degradation by Rhodopseudomonas palustris and identification of CouR, a MarR repressor protein that binds p-coumaroyl-CoA. J. Bacteriol. Feb [epub ahead of print}
2.Heiniger, E. K., Y. Oda, S. K. Samanta and C. S. Harwood. 2012. How post-translational modification of nitrogenase is circumvented in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively. Applied and Environ. Microbiol. 78:1023-32.
Lindemann, A., G. Pessi, A. L. Schaefer, M. E. Mattmann, Q.H. Christensen, A. Kessler, H. 3.Hennecke, H. E. Blackwell, E. P. Greenberg and C. S. Harwood. 2011. Quorum sensing in the soybean root-nodulating bacterium Bradyrhizobium japonicum: identification of isovaleryl-homoserine lactone, an unusual branched-chain signal. Proc. Natl. Acad. Sci. USA. 108:16750-16770.
4.Ahlgren, N. S., C. S. Harwood, A. L. Schaefer, E. Griaud, and E. P. Greenberg. 2011. Aryl-homoserine lactone quorum sensing in stem-nodulating photosynthetic bradyrhizobia. Proc. Natl. Acad. Sci. USA 108:7183-7188.
McKinlay, J. B. and C. S. Harwood. 2011. Calvin cycle flux, pathway constraints and substrate oxidation state together determine the H2 biofuel yield in photoheterotrophic bacteria. mBIO. March 22:2.
5.Hirakawa H, Y. Oda, S. Phattarasukol, C. D. Armour, J. C. Castle, C.K. Raymond, C. R. Lappala, A. L. Schaefer, C. S. Harwood and E. P. Greenberg. 2011. Activity of the Rhodopseudomonas palustris p-coumaroyl-homoserine lactone responsive transcription factor RpaR. J. Bacteriol. 193: 2598-2607.
6.Huang J.J., E. K. Heiniger, J. B. McKinlay and C. S. Harwood. 2010. Production of hydrogen gas from light and the inorganic electron donor thiosulfate by Rhodopseudomonas palustris. Appl. Environ. Microbiol. 76: 7717-7712. [epub ahead of print].
7.Gosse, J.L., B. J. Engel, J. C. Hui , C. S. Harwood, and M. C. Flickinger. 2010. Progress toward a biomimetic leaf: 4,000 h of hydrogen production by coating-stabilized nongrowing photosynthetic Rhodopseudomonas palustris. Biotechnol Prog. 26:907-918.
8.McKinlay, J. B. and C. S. Harwood. 2010. Carbon dioxide fixation as a central redox cofactor recycling mechanism in bacteria. Proc. Natl. Acad. Sci. USA 107:11669-11675.
9.Crosby, H. A., Heiniger, E. K., C. S. Harwood, and J. C. Escalante-Semerana. 2010 Reversible N-lysine acetylation regulates the activity of acyl-CoA synthetases involved in anaerobic benzoate catabolism in Rhodopseudomonas palustris. Mol. Microbiol. 75: 1007-1020.

10.McKinlay, J. B. and C. S. Harwood. 2010. Photobiological production of hydrogen gas as a biofuel. Curr. Opin. Biotechnol. 21:244-251.
11.Rey, F. and C. S. Harwood. 2010. FixK, a global regulator of microaerobic growth, controls photosynthesis in Rhodopseudomonas palustris. Mol. Microbiol. 75:1007-1020.
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