崔紫宁(青年教授)

时间:2016-12-09浏览:70设置


崔紫宁

青年教授,硕导
·联系方式:
·电子邮件:ziningcui@scau.edu.cn
·个人主页:
个人简介


崔紫宁,男,1981年10月出生,内蒙古人,理学博士,青年教授,硕士生导师。
主要从事糖化学及含杂环有机分子的设计合成以及生物活性研究工作。至今发表论文40余篇,申请中国发明专利12项,获得授权5项。主持国家自然科学基金2项,参与973项目1项,主持日本振兴会(JSPS)项目1项,主持和参与省部级项目10余项。入选2015年“珠江科技新星”,同年入选我校省级“千百十人才培养工程”重点培养。所在研究团队入选华南农业大学“十佳科研团队”。
学习经历
2004.09-2010.06   中国农业大学理学院应用化学系  硕博连读
2008.10-2009.09   日本千叶大学  联合培养博士
2008.06-2008.07   中国科学院研究生院  研究生暑期学校学习
2000.09-2004.07   中国农业大学国家化学理科基地班  本科
工作经历
2016.09-至今      华南农业大学群体微生物研究中心
                  广东省微生物信号与作物病虫害防控重点实验室  青年教授
2013.09-2016.06    华南农业大学农学院植物病理系
                  广东省微生物信号与作物病虫害防控重点实验室   副研究员
2012.04-2013.08   日本千叶大学  JST博士后研究员
2012.08-2012.11   北京大学  访问学者
2010.08-2012.07   日本千叶大学   JSPS外籍特别研究员
主要研究方向
活性小分子的设计与合成,农药学,药物化学。主要从事糖化学以及含杂环有机分子的设计合成以及生物活性研究工作。

承担科研项目情况

1. 国家自然科学基金(31570122):病原细菌多胺信号转导系统抑制剂的设计与合成。20161-201912月,项目主持人。

2. 国家重点基础研究发展计划——973计划(2015CB150600):微生物群体感应通讯系统与病害防控基础研究。20151-20198月,学术骨干。

3. 广东省公益研究与能力建设专项(2014A020210019):以拓扑异构酶II为靶点的新型氧杂蒽酮糖基缀合物的合成及构效关系研究。20151-201712月,项目主持人。

4. 广东省普通高校特色创新项目(自然科学)2014KTSCX031):糖缀合物作为植物抗病诱导剂的设计合成及其作用机制研究。20151-201712月,项目主持人。

5. 广州市“珠江科技新星”专项(201506010029):基于细菌群体感应信号分子的抑制剂设计与合成及作物病害防控。20154-20183月,项目主持人。

6. 华南农业大学校长科学基金(4200-K13014):含呋喃环2, 5-二取代-1, 3, 4-噻二唑类化合物的合成、生物活性及构效关系研究。20141-201612月,项目主持人。

7. 国家自然科学基金(31400544):桉树内生真菌及其抗桉树青枯病菌活性成分的研究。20151-201712月,主要成员。

8. 广东省普通高校国家级重大培育项目(自然科学类)(2014GKXM019):微生物群体感应通讯系统与病害防控基础研究。20151-201712月,主要成员。

9. 广东省公益研究与能力建设专项(2016A020217014):马铃薯三糖熊果酸衍生物作为新型H5N1进入抑制剂的构效关系及生物学研究。20164-201812月,主要成员

10. 广东省公益研究与能力建设专项(2015A020209133):柑橘溃疡病防控的新型杀菌增效剂研究。20161-201812月,主要成员。

11. 广东省普通高校青年创新人才项目(2014KQNCX034):隆缘桉和柠檬桉内生真菌抗菌活性成分及其诱导抗病性。20151-201712月,主要成员。

已结题项目:

12. 植物病虫害生物学国家重点实验室开放基金(SKLOF201411):水杨酸衍生物的设计合成及其抗病诱导活性研究。20141-201512月,项目主持人。

13.国家自然科学基金(21102173):糖基修饰水杨酸衍生物的合成及其抗病诱导活性研究。20121-201412月,项目主持人。

14.Molecular design, synthesis and bioactivity evaluation of novel glycosyl hydrazines. From the Japan Society for the Promotion of Science, Grant No. P10100, from Aug./2010 to Jul./2012,项目主持人。

15. 中国农业大学研究生科研创新专项优秀学位论文研究项目:糖基修饰的Schiff碱类衍生物的设计合成与生物活性研究。200912-20105月,项目主持人。

16. 国家自然科学基金(20802089):基于EcR/USP结构的新型IGRs先导化合物的生物合理设计。20091-201112月,主要成员。
代表性论著

1. Song, Gaopeng#; Li, Sumei#; Lei, Zhiwei; Li, Yibin; Li, Junhua; Liao, Yixian; Cui, Zi-Ning*. Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity. Org. Biomol. Chem., 2016, 14(28), 6691-6702cover paper.

2.  Li, Ya-Sheng#; Tian, Hao#; Zhao, Dongsheng#; Hu, De-Kun; Jin Hongwei; Song, Gaopeng*; Cui, Zi-Ning*. Synthesis and Bioactivity of Pyrazole and Triazole Derivatives as Potential PDE4 Inhibitors. Bioorg. Med. Chem. Lett., 2016, 26(15), 3632-3635.

3.  Wang, Chao; Liu, Xiaoling; Wang, Jing; Cui, Zining; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system in Pseudomonas aeruginosa. Sci. Rep., 2016, 6, 30949.

4.  Fan, Susu; Tian, Fang; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Yang, Cui Zi-Ning, Ching-Hong Yang*; He, Chenyang. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol., 2016, DOI: 10.1111/mpp.12415.

5.Zhou, Jia-Nuan#; Zhang, Hai-Bao#; Lv, Ming-Fa; Chen, Yu-Fan; Liao, Li-Sheng; Cheng, Ying-Ying; Liu, Shi-Yin; Chen, Shao-Hua; He, Fei; Cui Zi-Ning; Jiang, Zi-De; Chang, Changqing*; Zhang, Lian-Hui*. SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol. Plant Pathol., 2016, DOI: 10.1111/mpp.12376.

6.  Liu, Chunhui; Cui, Zi-Ning*; Yan, Xiaojing; Qi, Zhiqiu; Ji,Mingshan; Li, Xinghai*. Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2- aminopyrimidines against Botrytis cinerea. Molecules, 2016, 21(7), 828.

7. Song, Gao-Peng#, Hu, De-Kun#, Tian, Hao#, Li, Ya-Sheng, Cao, Yun-Shen; Jin, Hong-Wei; Cui, Zi-Ning*. Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives. Sci. Rep., 2016, 6, 22977.

8. Song, Gaopeng#; Li, Jianzuo#; Tian, Hao; Li, Yasheng; Hu, Dekun; Li, Ying; Cui, Zi-Ning*. Synthesis and Antitumor Activity of Novel N-Benzoyl-N'-substituted Pyrimidinyl (Thio)semicarbazide Derivatives. Lett. Drug Des. Discov., 2016, 13(4), 329-334.

9. Cui, Zi-Ning*; Li, Ya-Sheng; Hu, De-Kun; Tian, Hao; Jiang, Jia-Zhen; Wang,Yuan; Yan,Xiao-Jing. Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan, Sci. Rep., 2016, 6, 20204.

10. Song, Gaopeng; Zhao, Dongsheng; Hu, Dekun; Li, Yasheng; Jin, Hongwei; Cui, Zi-Ning*. Design, Synthesis and Biological Evaluation of Novel Tetrahydroisoquinoline Derivatives as Potential PDE4 Inhibitors, Bioorg. Med. Chem. Lett., 2015, 25(20), 4610-4614.

11.Song, Gao-peng; Li, Su-mei; Si, Hong-zong; Li, Yi-bin; Li, Ya-sheng; Fan, Ji-hong; Liang, Qian-qian; He, Hui-bing; Ye, Han-ming; Cui, Zi-Ning*. Synthesis and Bioactivity of Novel Xanthone and Thioxanthone L-Rhamnopyranosides, RSC Adv., 2015, 5(45), 36092-36103.

12. Li, Chengkun; Jiang, Lin; Wang, Yue; Wan, Fuxian; Zhang, Peizhi; Li, Ying; Cui, Zi-Ning*. Design, Synthesis and Biological Activities of N-(Substituted benzoyl)-N′-(5-methoxyl-2- methylsulfanylpyrimidin-4-amino) (thio) Ureas, Chin. J. Org. Chem., 2014, 34(11), 2296-2303.

13. Cui, Zining*; Ito, Jun; Dohi, Hirofumi; Amemiya, Yoshimiki; Nishida, Yoshihiro. Molecular Design and Synthesis of Novel Salicyl Glycoconjugates as Elicitors against Plant Diseases, PLOSOne, 2014, 9(9), e108338.

14. Cui, Zining*; Li, Xinghai; Tian, Fang; Yan, Xiaojing. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain, Int. J. Mol. Sci., 2014, 15(5), 8941-8958.

15. Cui, Zining*; Su, Hang; Jiang, Jiazhen; Yang, Xinling; Nishida, Yoshihiro. Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives, Int. J. Mol. Sci., 2014, 15(4), 6741-6756

16. Cui, Zining*; Liang, Zhibin; Tian, Fang; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (I), Chin. J. Pestic. Sci., 2014, 16(3), 252-258.

17. Cui, Zining*; Tian, Fang; Liang, Zhibin; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (II), Chin. J. Pestic. Sci., 2014, 16(4), 394-399.

18. Cui, Zining*; Li, Xing-Hai; Nishida, Yoshihiro. Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan, Lett. Drug Des. Discov., 2014, 11(7), 877-885.

19. Li, Xing-Hai; Pan, Qiang; Cui, Zi-Ning*; Ji, Ming-Shan; Qi, Zhi-Qiu. Synthesis and Fungicidal Activity of N-(2,4,5-trichlorophenyl)-2-Oxo- and 2-Hydroxycycloalkylsulfon amides, Lett. Drug Des. Discov., 2013, 10(4), 353-359.

20. Li,Xing-Hai#;Cui,Zi-Ning# (first co-author); Chen,Xiao-Yuan; Wu,De-Cai; Qi, Zhi-Qiu; Ji, Ming-Shan. Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity, Int. J. Mol. Sci., 2013, 14(11), 22544-22557.

21. Cui, Zi-Ning; Shi, Yan-Xia; Zhang, Li; Ling, Yun; Li, Bao-Ju; Nishida, Yoshihiro; Yang, Xin-Ling. Synthesis and Fungicidal Activity of Novel 2, 5-Disubstituted-1, 3, 4-oxadiazole Derivatives, J. Agric. Food Chem., 2012, 60(47), 11649−11656.

22.Cui, Zi-Ning; Shi, Yan-Xia; Cui, Jing-Rong; Ling, Yun; Li, Bao-Ju; Yang, Xin-Ling. Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Chem. Biol. Drug Des., 2012, 79(1), 121-127.

23.Cui, Zi-Ning; Yang, Xin-Ling; Shi, Yan-Xia; Uzawa, Hirotaka; Cui, Jing-Rong; Dohi, Hirofumi; Nishida, Yoshihiro. Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety. Bioorg. Med. Chem. Lett., 2011, 21(23), 7193-7196.

24. Cui, Zi-Ning; Zhang, Li; Huang, Juan; Yang, Xin-Ling; Ling, Yun. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing FuranIII. Chin. J. Chem., 2010, 28(7), 1257-1266.

25. Cui, Zi-Ning; Zhang, Li; Huang, Juan; Ling, Yun; Yang, Xin-Ling. Synthesis, Insecticidal Activity and 3D-QSAR Studies on Diacylhydrazine Derivatives Containing Furan. Chin. J. Org. Chem., 2010, 30(10), 1482-1491.

26. Cui, Zi-Ning; Ling, Yun; Li, Bao-Ju; Li, Yong-Qiang; Rui, Chang-Hui; Cui, Jing-Rong; Shi, Yan-Xia; Yang, Xin-Ling.Synthesis and Bioactivity of N-benzoyl-N'-[5-(2'- substituted phenyl)-2-furoyl] semicarbazide Derivatives. Molecules, 2010, 15(6), 4267-4282.

27. Cui, Zi-Ning; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jing-Rong; Wang, Rui-Qing; Yang, Xin-Ling. New Class of Potent Antitumor Acylhydrazone Derivatives Containing Furan. Eur. J. Med. Chem., 2010, 45(12), 5576-5584.

28. Zhang, Li; Cui, Zi-Ning; Yin, Bin; Yang, Guang-Fu; Ling, Yun; Yang, Xin-Ling. QSAR and 3D-QSAR Studies of the Diacyl-hydrazine Derivatives Containing Furan Ring Based on the Density Functional Theory. Sci. China: Chem., 2010, 53(6), 1322-1331.

29. Cui, Zi-Ning; Ma, Yong-Qiang; Ling, Yun; Yang, Xin-Ling*. Crystal Structure of Hexa-m2-chloro-m4-oxo- tetrakis [(1, 4-dioxane-kO4) copper(II)]. Analytical Sciences-X-ray Structure Analysis Online, 2009, 25(7), 79-80.

30. Cui, Zi-Ning; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*; Chen, Fu-Heng. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing FuranI. Chin. J. Chem., 2008, 26(5), 916-922.

31. Cui, Zi-Ning; Zhang, Li; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*. 3D-QSAR Studies on Diacylurea Derivatives Containing Furan Moiety. Acta Chim. Sinica, 2008, 66(12), 1417-1423.

32. Cui, Zi-Ning; Wang, Zhen; Li, Ying; Zhou, Xin-Yu; Ling, Yun; Yang, Xin-Ling*. Synthesis and Insecticidal Activity of Diacylhydrazine Containing Furan. Chin. J. Org. Chem., 2007, 27(10):1300-1304.

33. Cui, Zi-Ning; Yang, Lin; Li, Xi-Chen; Wang, Zhen; Yang, Xin-Ling. Progress in the Study on the Synthesis and the Activities as Insect Growth Regulators of 2, 5-Disubstituted 1, 3, 4- Oxadiazoles.Chin. J. Org. Chem., 2006, 26(12), 1647-1656.

申请专利:

1. 崔紫宁,陈昱帆,程莹莹,周佳暖,刘诗胤,陈少华。含呋喃环2,5-二取代-1,3,4-噻二唑类化合物在制备致病疫霉菌抑菌剂中的应用,中国发明专利。ZL 201310631983.4, 2016-3-30

2. 崔紫宁,程莹莹,刘诗胤,陈昱帆,周佳暖,陈少华。一种含呋喃环2, 5-二取代-1, 3, 4-噻二唑类化合物及其制备方法和应用,中国发明专利。ZL 201310629477.1, 2015-10-28

3. 崔紫宁,周佳暖,刘诗胤,程莹莹,陈少华。一种苯基取代噻吩甲酰肼类化合物及其制备方法和应用,中国发明专利。ZL 201310574554.8, 2015-06-17

4. 杨新玲,崔紫宁,凌云,徐炎,张元新。N-5-取代苯基-2-呋喃甲酰基类化合物及其制备方法与应用,中国发明专利。ZL 201110100774.8, 2014-08-20

5. 杨新玲,李映,凌云,崔紫宁,胡君,苗宏建,陈馥衡。一种取代苯甲酰胺基甲酸甲酯类化合物及其制备方法与应用,中国发明专利。ZL 200710303669.8, 2009-12-16

6. 崔紫宁,胡德坤,田浩,李亚胜,宋高鹏,刘星宇。N’-5-(取代苯基)-2-呋喃甲酰基-5-丙基-1H-吡唑-3-甲酸乙酯类化合物及其制备方法与应用。2016201610383248.X (审查中)

7. 崔紫宁,田浩,胡德坤,李亚胜,宋高鹏,刘星宇。S-(5-取代-1,3,4-噻二唑)-(5-取代苯基)-2-呋喃硫代甲酸酯类化合物及其制备方法与应用。2016201610382784.8

(审查中)

8. 陈少华,廖立胜,崔紫宁,周佳暖,贺飞。一种利用铜绿假单胞菌高效降解高效氯氰菊酯的方法。2015, 11pp, CN 104671430 A, 20150603(审查中)

9. 陈少华,廖立胜,崔紫宁,周佳暖,贺飞。一种高效降解农药的方法。201511pp CN 104548470 A20150429(审查中)

10.杨新玲,崔紫宁,凌云,黄娟,张莉,陈馥衡。一类具有抗肿瘤活性的芳基呋喃甲酰腙类化合物, 中国发明专利。2009, 10pp. CN 101402621 A, 20090408(审查中)

11. 杨新玲,崔紫宁,凌云,黄娟,张莉,陈馥衡。一类具有抗肿瘤活性的苯甲酰腙类化合物, 中国发明专利。 2009, 10pp. CN 101402620 A, 20090408(审查中)

















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